Intobac Eye Drops (Tobramycin)

Therapeutic Group: Ophthalmic Antibacterial Preparations

Intobac 0.3% eye drops: Each ml contains Tobramycin USP 3 mg.

Intobac is a broad-spectrum, aminoglycoside antibiotic of bacteriocidal type of action. It works by inhibition of bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome.

Intobac eye drops is a topical antibiotic indicated in treatment of external bacterial infections of the eye and its adnexa caused by susceptible organisms: Gram-positive microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus sp. of group A beta-hemolytic and some nonhemolytic species. Gram-negative microorganisms: Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella sp., Proteus mirabillis, Proteus vulgaris, Haemophilus influenzae, Morganella morganii, some strains of Neisseria, Acinetobacter calcoaceticus, Providentia, Serratia, Salmonella sp

Adults If the infection is mild to moderate, 1 or 2 drops into the affected eye(s) every 4 hours. In severe infections, 2 drops into the eye(s) every hour until there is improvement ,following which treatment should be reduced prior to discontinuation. Children Doctor will tailor a dose for the children

Localized ocular toxicity and hypersensitivity, including lid itching and swelling, conjunctival erythema and lacrimation

Sensitivity to topically applied aminoglycosides may occur in some patients. If a sensitivity reaction to tobramycin occurs, discontinue use. Prolonged use may lead to skin sensitisation or result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs appropriate therapy should be initiated

Tobramycin eye drops is contraindicated in patients hypersensitive to tobramycin or to any of the ingredients of the formulation.

There are no adequate and well-controlled studies of tobramycin in pregnant women. Therefore, this drug should only be used during pregnancy, if the potential benefits outweigh the possible risks to the fetus. Tobramycin is unlikely to pass into the breast milk in large amounts and little would be absorbed by the infant. Because of the potential for adverse reactions in nursing infants, a decision should be made whether to discontinue nursing the infant or discontinue the drug.

Signs and symptoms of overdose may be similar to side effects as described above Storage Protect from light. Store below 25�C. Keep out of reach of children. Do not use more than 4 weeks after opening

Intobac 0.3% eye drops: Each plastic dropper bottle containing 5 ml eye drops